In 2000, approximately 40,000 marrow transplants were performed worldwide. In the field of bone marrow transplantation (BMT), an autologous transplant involves bone marrow harvesting from the patient, and feeding the marrow back to the same patient following treatment with high-dose chemotherapy. An allogeneic transplant refers to the procedure of harvesting bone marrow from a healthy donor and giving it to the patient who has received high doses of chemotherapy and radiation.
Because both of these harvesting methods are expensive and tedious, the MarrowMiner E-Team developed an innovative device and method for rapidly harvesting bone marrow and the stem cells bone marrow contains. The team incorporated as StemCor Systems.
In 2008, the team signed an agreement with Hospira, Inc. to develop and commercialize StemCor's proprietary system for the harvest of bone marrow.
The traditional method for resisting a flood involves filling individual bags with sand and stacking them to form a flood berm. This method is costly and slow, however, and requires large amounts of manual labor. This E-Team developed a new invention, the Flood Floatation Wall (FFW), which addresses the problems associated with traditional methods of resisting floods. The FFW is self-deploying: the user pre-positions the device at the anticipated flood level and then evacuates the area as needed. It consists of a flexible tubular flood chamber, skirts, and an air-filled flotation collar. As floodwater enters the flood chamber, it expands the chamber and activates the flotation collar, which rises to block incoming water. The FFW incorporates reasonable manufacturing costs, ease of transport, reusability and functional utility in one.
The Electrical and Computer Engineering faculty at the Rose-Hulman Institute of Technology and the Florida Institute of Technology are collaborating on undergraduate entrepreneurial projects in the area of wireless communication and radio-related fields. The Wireless Entrepreneurs Program builds on existing design curricula at both schools, but follows the entrepreneurial model developed at Rose-Hulman, rather than a traditional engineering course format. In the collaboration, faculty and students work on two projects. In one project, students from each school work together on multi-institutional teams on a development project. The student project focuses on developing interactive modules that visually depict and/or simulate the principles involved in cellular and PCS systems. Each team researches, proposes, and develops their own projects for a wireless application, starting in the teams’ junior years. The teams submit a proposal to a committee composed of industry and faculty from both institutions.
The second project involves the development of a small auxiliary radar device that senses the presence of a vehicle in an unsafe zone or detects the presence of a vehicle that is approaching with excessive speed. The project involves the evaluation of both technologies and techniques for sensing as well as providing wireless means for communicating to the dashboard. While faculty and students at each institution work independently, the faculty shares the team findings, approaches, and experiences as development progresses from concept through design, developing, and testing.
Child loss is a real fear for child caregivers in today’s society. In 2001, the police received 2,000 lost-child cases. Although the majority of these children were recovered within hours, time spent finding the child meant time spent keeping the family in distress. To deter this problem, this E-Team developed Wee Know, a child loss prevention system.
Wee Know consists of two wireless communication devices: one for the child and one for the caretaker. The child’s device, about the size of a wristwatch, attaches to the child’s wrist; the adult’s device resembles a pager. The devices consist of integrated circuits (ICs) that handle all functions of the system, utilizing radio frequency (RF) for communication. The team’s current prototype integrates a RF transmitter and receiver produced by Linx Technologies. To ensure the correct signal passes between the child and caretaker devices, the communication signal must be encoded. Encoding distinguishes the RF signal from other signals that could cause interference. If the child and adult devices get too far away to properly communicate, an alarm signals.
The Wee Know E-Team consists of four undergraduate students in computer, electrical and mechanical engineering. They work with two faculty members in electrical engineering, and a business advisor from the Wesley J. Howe School of Technology Management.
California Institute of Technology, 2002 - $12,100
The Equigene Research E-Team used racehorses to identify the genes involved in athletic performance and disease susceptibility. Working with industry advisors, the E-Team, consisting of two PhD candidates in Biology, created a database of single nucleotide polymorphisms (SNPs) strongly associated with superior and/or diseased cardiovascular function in thoroughbreds. The team genetically evaluated horses for their racing and breeding potential, propensity for injury, and susceptibility to illness. Using proprietary methods to create DNA tests that allow precise determination of clients' horses’ genetic composition, the team advised horse owners, breeders, and trainers on how to best manage their stock.
Every visit a patient makes to the hospital generates at least one medical report. Because of high volume, hospital staffs are unable to keep up manual entry of reports into computer systems for analyzing and statistics keeping. Manual processing of these reports can lead to breaches in patient confidentiality and misplaced files.
For this reason, this E-Team, consisting of two biomedical engineering undergraduates working with faculty and an industry advisor, has developed MedfoLink, a computerized system for processing hospital patient records. MedfoLink adapts the data contained in the Unified Medical Language System (UMLS), a medical language source database containing over 2.1 million concept names in over sixty different biomedical vocabularies, for use by language processing systems. This allows MedfoLink to transform the data from patient records into a format appropriate for computer analysis. With this analysis, healthcare professionals will have the tools to identify trends in the patient population.
The growing industry of mountain biking faces problems as cycle frame manufacturers face design, materials, and manufacturing constraints in their attempts to reduce frame weight while increasing strength. These limitations result from the disadvantages of conventional fusion welding to join bicycle frame members. To eliminate these constraints, the Interlink E-Team is applying innovative Friction Stir Welding (FSW) technology to bicycle frame assembly. Introduced in 1991, FSW is a cutting-edge solid-state joining technology developed by The Welding Institute, a nonprofit welding consortium. FSW is a simple mechanical process in which a cylindrical pin made of tool steel is rotated, plunged and traversed along a weld joint to create a solid-state, high strength joint.
FSW improves bicycle frames in five important ways.
FSW improves frame strength and rigidity with greater joint strengths and fatigue life; elimination of solidification defects; reduced thermal input; and the ability to join higher strength aerospace alloys that are not weldable with fusion welding.
FSW lowers frame weights by reducing structural over-design, minimizing join build-up, and expanding the use of higher strength-to-weight ratio aerospace alloys.
FSW reduces manufacturing costs by eliminating fusion weld consumables, reducing the number of manufacturing steps, and increasing process automation.
FSW providers greater freedom in mechanical design through enhanced joint properties and alloy choices.
FSW is an environmentally friendly and safe process with no noxious byproducts.
The Interlink E-Team, spread among many institutions, consists of two MBA candidates from the Tuck School of Business, a graduate student in materials science engineering from the University of California at Berekely, and various faculty and industry advisors. The team is designing and building a mountain bike using FSW; completing metallurgical and mechanical testing of simulation joints; drafting and filing a patent for the frames and sub-assemblies; and generating a business plan. Interlink plans to target the high-performance mountain bike market.
Many restaurants serve fountain drinks made of mixed syrup and CO2. Servers and managers monitor syrup levels to ensure quality beverages with manual techniques, such as observing the color of the drinks, lifting the syrup canisters to judge weight, and visually observing containers. In a busy establishment, syrup levels often run low or completely out before a supervisor or server notices, causing poor customer service, poor quality drinks, or interrupted service.
To remedy this problem, six undergraduates students developed the SOS, or Syrup Out Signal. SOS monitors fluid levels in CO2 canisters and syrup boxes and alerts restaurant staff when the ingredients reach low levels. With syrup in the tubing, the circuit generates a steady voltage output. But when air replaces the syrup in the line, the voltage lowers. This sudden change in voltage causes a radio transmitter to signal a receiver, which supplies current to a light-emitting diode and turns on a warning light, alerting the user to low syrup levels.
Every year, waterborne viruses and bacteria kill millions of children under the age of five. Improved water supply and sanitation could prevent many of these deaths; currently, however, one out of four people lack access to clean water. Though the technology for disinfecting drinking water exists, high costs make it inaccessible for many. In response to this problem, this E-Team has developed the UV-Tube, a highly effective method for disinfecting drinking water that is also cost effective. The UV-Tube, a very simple technology, eliminates harmful microorganisms directly from the water source, using ultraviolet (UV) light as a disinfectant. The UV-Tube technology is environmentally friendly, deactivating pathogens without generating harmful byproducts. In addition, the technology adapts to different communities and circumstances; users can construct the UV-Tube from locally available parts. It also operates passively, without extensive maintenance or monitoring.
Currently the E-Team plans to integrate changes from their studies into a new design, investigate additional potential materials (recycled plastic soda bottles, stainless steel, and pottery), redesign the UV-Tube, and test the new design in a real-world situation. The team hopes to complete a list of potential materials and adaptations for users in all types of geographic locations.
The UV-Tube project consists of several graduate students, one in civil and environmental engineering with field experience in Patzcuaro, and the other in energy and resources. They work with an undergraduate in environmental science, a member of the Lawrence Berkeley Laboratory, and the director of the Renewable and Appropriate Energy Laboratory, who is also a faculty member, and are advised by Dr. Lloyd Connelly, a representative of the Energy Sector Management Assistance Group, and the president of Grupo Interdisciplinario de Technolgías Rural y Apropiada in Patzcuaro.
With support from the NCIIA, the Georgia Institute of Technology, in collaboration with Emory University, established an innovative multidisciplinary training program, entitled Integrated Approach to Technological Innovation (IATI). The IATI Program equips science and engineering PhD students with the skills and multidisciplinary perspective necessary to succeed as entrepreneurs. IATI also produces science and engineering (S & E) dissertations with both technical merit and market relevance, and provides Master of Science Management and Doctor of Jurisprudence students with practical experience in a technical research environment.
As part of the IATI Program, students in management, law, and economics team with S&E students to explore the market potential of the new technologies developed by the S&E students. Team projects focus on research in four primary S&E areas critical to US innovation: biomedical engineering, manufacturing, microelectronics, and nanotechnology. Advised by faculty and industry mentors, these teams develop the technical, legal, and business issues involved with moving fundamental research to the marketplace. Fifteen students participate in IATI each year, joining E-Team projects for the duration of the two-year program.