DiverRx -- Preventing Recurrent Diverticulitis

Diverticulitis is a disease characterized by the acute inflammation of a diverticulum (mucosal outpouching) of the colon. It’s accompanied by intense lower abdominal pain and requires emergency treatment, often involving hospitalization, with about 25% of these patients going on to have recurring attacks. The only treatment available to prevent recurrent attacks is colon resection, but many patients at risk for recurrence of diverticulitis are not surgical candidates due to advanced age or co-morbidities.

This E-Team is developing a device to address the clinical need of preventing recurrence of diverticulitis in a less invasive manner than elective colon resection. The device, an endoscopic RF ablation balloon catheter, will apply RF energy locally to the diverticular tissue, inducing a fibrotic response similar to that utilized by BARRX Medical in treating Barrett’s esophagus. The goal is to target diverticula for treatment while preserving healthy colon tissue.

The target market is relatively open (they’ve talked with several experts), with no prior minimally invasive methods or competitors that have successfully prevented recurrence of diverticulitis.