percutaneous catheter ablation of atrial fibrillation

A Novel System to Improve the Efficacy of Percutaneous Catheter Ablation of Atrial Fibrillation

Stanford University, 2005 - $7,250

Atrial fibrillation (AF) is a cardiac rhythm disorder that can lead to heart palpitations, chest pain, and clot formation that can lead to strokes. Medications used to control the symptoms of AF have had limited success and come with significant side effects. Recent research suggests that AF is caused by electrically abnormal cells in the right and left side pulmonary veins; with this in mind, percutaneous catheter techniques have been developed in which a catheter is used to ablate (destroy) the conducting tissue around the abnormal cells, electrically isolating them so that they cannot initiate AF. However, this procedure has had limited success due to the fact that the catheter cannot always access the right-sided pulmonary veins given their physical location in the body and the variability of pulmonary vein anatomy from person to person.

To address this issue, this E-Team developed a novel sheath system that can target a catheter directly toward the right-sided pulmonary veins, leading to more effective AF ablations. The sheath system utilizes an anchored trans-septal sheath and an inner, pre-shaped guiding sheath to direct the ablation catheter directly toward right-sided pulmonary veins. The team also designed several inner sheaths to optimize the targeting of the catheter depending on whether the right superior, right inferior, or both right-sided pulmonary veins together are being isolated.

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